Real experiences with clinically developed formulation
What our customers say
Thousands of customers worldwide trust our formulations to support their daily wellbeing. From long-term probiotic users to individuals seeking targeted microbiome solutions, their feedback reflects the consistency, quality and scientific foundation behind every product.
Discover how our research-driven approach translates into real-world results.
Summer essentials
Italy summer offer ❄️ Cool-stock Pack Your probiotic summer supply Stock up, save, and help protect your supplements even outside the fridge. With the Cool-stock Pack, you get everything you...
Summer essentials
Summer essentials
Cosmetic restorative cream.Designed to support the skin’s natural barrier function. Dermatologically tested.
Four areas of expertise. One scientific approach.
What are
At drdesimone, every formulation is developed with a research-driven mindset and a precise understanding of the human microbiome. From high-potency probiotics for gut balance to targeted oral mucosa support and microbiome-based skin barrier care, each line is designed to address specific physiological needs with defined strains, controlled composition and consistent quality.
CDS22-FORMULA
CERABEST
OXXYSLAB
MUCOMIXX
All our products stem from the research of Professor Claudio De Simone (MD, FAGA), a leading figure in microbiota science.
With over 30 years of scientific backing, his exclusive formulations, like the renowned CDS22-formula (known in literature as the "De Simone Formulation" - DSF), are designed to support you with unmatched quality and precision.
Defined strains.
Each product is developed using clearly identified bacterial strains and precisely balanced compositions, following the scientific principles established by the inventor of the original De Simone Formulation (DSF).
This approach ensures consistency, stability and reproducibility — maintaining the same rigor, quality standards and scientific integrity across every product.
Unmatched Potency for Maximum Results.
Concentration is key to effectiveness. Scientific evidence shows that higher doses are necessary to ensure successful colonization and provide robust support. With up to 16 times the strength of leading competitors, our formulation delivers the high-impact potency your gut balance deserves.
Billion live bacteria per dose
We care about your order
INSULATED PACKAGING · ICE GEL PACKS · LIVE TRACKING · EXPRESS DELIVERY
We assemble your order from chilled stock, using insulated packaging and gel packs. The parcel is sealed just minutes before DHL collects it to minimise temperature variations.
You receive live tracking at pickup, with the option to adjust delivery day, time or location.
Delivery times are indicative and depend on destination and service selected.
Typical timelines from pickup:
Some destinations may require extended delivery windows (see the DHL Remote Areas list). Please review our Shipping Policy.
Our Most
Discover our most requested formulations, developed with defined strains and precise compositions for gut balance, oral mucosa, skin barrier care, and high-performance support.
Below you’ll find answers to the most common questions about our probiotic and microbiome-based formulations. From scientific background and strain definition to dosage, storage and delivery, we aim to provide transparent and reliable information.
If you don’t find the answer you’re looking for, our support team is always available to assist you.
You can purchase our products directly from drdesimone.net. However, in some regions, certain products may only be available through official local distributors. Please check our website for more details on availability in your area.
Although there are no significant risks associated with the use of CDS22-formula, the adaptation of the intestinal flora to the bacteria it contains may occasionally cause temporary abdominal bloating. In such cases, we recommend reducing the dosage for a few days.
Purchasing directly from DrDeSimone.net guarantees that you receive authentic products adhering to the original formulations created, developed and licensed by Prof. De Simone.
The De Simone Formulation is a unique blend of specific bacterial strains developed by Prof. De Simone, extensively studied and recognized globally for its effectiveness in treating various intestinal health issues.
Our products are available in different formats, including sachets and drops for infants, to meet diverse needs. Our customer support can help guide your choice based on your health requirements.
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