Real experiences with clinically developed formulation
What our customers say
Thousands of customers worldwide trust our formulations to support their daily wellbeing. From long-term probiotic users to individuals seeking targeted microbiome solutions, their feedback reflects the consistency, quality and scientific foundation behind every product.
Discover how our research-driven approach translates into real-world results.
For a long time, I struggled with irritable bowel syndrome (IBS). Abdominal pain, bloating, constant digestive discomfort… My everyday life had become a real challenge. It was difficult to enjoy even the simplest things when I never knew how my stomach would react.
Then I discovered CDS22-formula 112B – 20 Capsules, and honestly, it was a real turning point for me!
Since I started taking it, I've noticed a significant improvement in my digestive comfort. I've finally found the peace of mind I thought I'd lost. I can go out, enjoy meals, and appreciate the little pleasures of everyday life without constantly worrying about my digestive issues.
I finally feel like I've got my normal life back, and that feeling is priceless!
Of course, everyone's body is different, but for me, this product has made an incredible difference.
Today, I finally feel like myself again, and I wanted to share my experience because I know just how much IBS can affect your quality of life.
We have been using CDS22 for our dog, who has intestinal IBD, and we are very happy with the results. Since starting it, her digestive condition has been much more stable and the episodes/crises, which used to be quite frequent, have significantly decreased. In our experience, it has been a very helpful product for supporting her intestinal health and maintaining greater stability over time.
Devo dire che da quando uso la crema la mia pelle è assolutamente più sana. Dire che sono contenta è poco . Annullati arrossamenti, pruriti, strane reazioni. Sono entusiasta
Eccezionale!! Grazie per il vostro lavoro.
Ottimo prodotto
La sto usando dopo il mare e dona una sensazione di freschezza incredibile. Si assorbe subito e non lascia patine o olii sulla pelle, ma si sente che la nutre in profondità.
Profumo delicato, di pulito, svanisce subito e rende l'applicazione una coccola.
Ich verwende dieses Produkt für meine kleine Tochter. Ich füttere sie schon seit vielen Jahren mit DSF-Nahrung und freue mich, sie ihr geben zu können, da ich sie für qualitativ hochwertig halte.
Die Packung enthält Eis. Ausgezeichnet!
Lo sto usando la mattina, prima delle mie escursioni in bicicletta. Mi sta aiutando a sopportare meglio lo sforzo prolungato.
Mi hanno tolto la sensazione di pancia gonfia e aria. ne prendo 2 la mattina e 2 la sera
Ich gebe zu, ich habe sie nur gekauft, weil sie so hübsch ist … aber sie ist auch praktisch und für viele kleine Dinge nützlich. Ich habe sie in beiden Ausführungen.
I have been using the De Simone Formulation for years and wanted to try this new product.
I work out four times a week and chose the 800 dosage. I have noticed an improvement in my endurance, not only during my workouts but also on recovery days.
I also monitor my sleep with an activity tracker, so it is not just a feeling: I am genuinely sleeping better… I have even started dreaming again!
can oxxyslab be taken together with CDS22? I usually take the sachets.
thank you
Prodotto ineguagliabile. Da sempre. Spedizione perfetta e con ghiacci. Altissima qualità su tutto.
Ho fatto una bella riserva di Mucomixx. Mi risana IMMEDIATAMENTE le gengive, meglio di qualsiasi altro prodotto ! Grazie
E' il secondo tubo che ricompro. Questa crema, oltre ad essere estremamente vellutata e rinfrescante, mi ha migliorato un segno rimasto dopo un intervento laser venuto male, in una zona delicata (vicino alla bocca). La uso su tutto il viso e il collo almeno 2/3 volte al giorno e ho notato che la pelle in generale ha ripreso tono e luminosità. Ho 65 anni.
Honestly, nothing else compares. I was devastated when I could no longer find it (the original) anywhere.
This is the only product that truly works for me.
Professor De Simone’s original formulations
Research, experience and solutions developed for you.
Four areas of expertise. One scientific approach.
What are
At drdesimone, every formulation is developed with a research-driven mindset and a precise understanding of the human microbiome. From high-potency probiotics for gut balance to targeted oral mucosa support and microbiome-based skin barrier care, each line is designed to address specific physiological needs with defined strains, controlled composition and consistent quality.
CDS22-FORMULA
CERABEST
OXXYSLAB
MUCOMIXX
All our products stem from the research of Professor Claudio De Simone (MD, FAGA), a leading figure in microbiota science.
With over 30 years of scientific backing, his exclusive formulations, like the renowned CDS22-formula (known in literature as the "De Simone Formulation" - DSF), are designed to support you with unmatched quality and precision.
Defined strains.
Each product is developed using clearly identified bacterial strains and precisely balanced compositions, following the scientific principles established by the inventor of the original De Simone Formulation (DSF).
This approach ensures consistency, stability and reproducibility — maintaining the same rigor, quality standards and scientific integrity across every product.
Unmatched Potency for Maximum Results.
Concentration is key to effectiveness. Scientific evidence shows that higher doses are necessary to ensure successful colonization and provide robust support. With up to 16 times the strength of leading competitors, our formulation delivers the high-impact potency your gut balance deserves.
Billion live bacteria per dose
We care about your order
INSULATED PACKAGING · ICE GEL PACKS · LIVE TRACKING · EXPRESS DELIVERY
We assemble your order from chilled stock, using insulated packaging and gel packs. The parcel is sealed just minutes before DHL collects it to minimise temperature variations.
You receive live tracking at pickup, with the option to adjust delivery day, time or location.
Delivery times are indicative and depend on destination and service selected.
Typical timelines from pickup:
Some destinations may require extended delivery windows (see the DHL Remote Areas list). Please review our Shipping Policy.
Our Most
Discover our most requested formulations, developed with defined strains and precise compositions for gut balance, oral mucosa, skin barrier care, and high-performance support.
Below you’ll find answers to the most common questions about our probiotic and microbiome-based formulations. From scientific background and strain definition to dosage, storage and delivery, we aim to provide transparent and reliable information.
If you don’t find the answer you’re looking for, our support team is always available to assist you.
You can purchase our products directly from drdesimone.net. However, in some regions, certain products may only be available through official local distributors. Please check our website for more details on availability in your area.
Although there are no significant risks associated with the use of CDS22-formula, the adaptation of the intestinal flora to the bacteria it contains may occasionally cause temporary abdominal bloating. In such cases, we recommend reducing the dosage for a few days.
Purchasing directly from DrDeSimone.net guarantees that you receive authentic products adhering to the original formulations created, developed and licensed by Prof. De Simone.
The De Simone Formulation is a unique blend of specific bacterial strains developed by Prof. De Simone, extensively studied and recognized globally for its effectiveness in treating various intestinal health issues.
Our products are available in different formats, including sachets and drops for infants, to meet diverse needs. Our customer support can help guide your choice based on your health requirements.
Didn't find the answer?
